APDS (3-Aminopyridyl-N-hydroxysuccinimidyl Carbamate) is a pre-column derivatization reagent used for primary and secondary amine and amino acid analyses in LC/MS and LC/MS/MS.
Derivatization with APDS followed by separation and detection by LC/MS allow distinction of respective amino acids by m/z even if the retention times are the same and, thus, the analysis time can be shortened significantly.
In addition, APDS is designed to increase the ionization efficiency, allowing highly sensitive amino acid analysis in LC/MS/MS, especially by triple quadrupole.