Exosomes are known to adsorb to the wall of plastic tubes, which considerably affects the exosome yield and other outcomes. In addition, as exosomes are damaged by freeze and thaw, protective agents suitable for storing exosomes have been desired. With this background in mind, Fujifilm Wako developed the EV-Save™ series of adsorption prevention/cryoprotection reagents for exosomes. EV-Save™ considerably inhibits adsorption of exosomes to the tube walls and protects exosomes from the freeze-thaw damage.